We are a synthetic bioorganic/materials group focused on applying the tools of synthetic organic chemistry to the challenges of biology, medicine and materials science.Our chemistry involves developing new unnatural amino acids and carbohydrates and making more stable artificial oligosaccharides and peptides for immunological and anti-cancer applications, and using these biomaterials as the basis for new classes of sustainable materials for a variety of applications including smart drug-delivery, environmentally benign plastics, and for use as nano probes for medical diagnostics. Our team includes synthetic chemists, computational chemists, analytical chemists, supramolecular and nanoscale chemists and engineers, biologists, biochemists and materials scientists! We have broad interests in science.
Areas of Research Interest
We are using synthetic organic chemistry in combination with computational techniques to design and make interesting new carbohydrates, peptides and polymers for biological, supramolecular, immunological, material and medical applications. We are particularly interested in projects that involve a multidisciplinary strategy at the interface of chemistry, materials science and biology.
Academic and Industrial Collaboration
We are always interested in applying our expertise in bioorganic chemistry to other challenges. Interested academic and industrial partners are encouraged to contact Dr. Trant to explore possible areas of mutual interest and benefit. For Canadian industrial partners, further financial support may be obtained through a joint proposal to MITACS or NSERC Alliance
These are expected to start April-June 2020. Position is open to individuals holding a PhD in chemistry or a related discipline.
For all positions:Individuals from under-represented groups are especially encouraged to apply. This includes ethnic, religious, sexual, disability, and gender minorities as well as first-generation university students (those whose parents do not hold university degrees). Individuals who have faced obstacles that have hindered their education and productivity are encouraged to apply. Nationality will not be considered in any personnel decision, although it does play a role in the cost of tuition at the University of Windsor for graduate students.
Grad Students For Sep. 2020
Candidates can be interested in synthetic or computational chemsitry with some experience in either field required. A publication record is not required. Special encouragement is given for those with non-traditional backgrounds.
***Generic emails will not be answered.
If you are interested, please send an email to Dr. Trant and include your resumé/CV and a copy (a screenshot is fine, official is definitely not required) of your high school or university transcript along with a short self-introduction and the reason why you are interested!
@nmr_chemist @pharmacognosy Like bioprospecting? And doing SAR on natural products? And medchem synthesis (but sorta total syn, but on designer molecules so not as lengthy) working with computational chemists and molecular biologists to do drug discovery?
We're looking for people for 2021......
This position is open to individuals holding a PhD in molecular biology, cell biology, genetics, proteomics or a related discipline. The position is one year renewable indefinitely depending on performance. This is a leadership position with the opportunity to be highly involved in group, project, and budget management as well as directing the cell and molecular biology subprogram within the Trant research group. The individual will be working very closely with our highly talented collaborators in the deparment of biomedical sciences here at UWindsor, and with our external collaborators across Canada and around the world. The initial focus of the position is to establish the baculovirus expression system in the Trant lab to support a number of projects. There is also a current focus on microbiology, enzymatic engineering, and whole cell fermentation to obtain new natural products from both yeast and bacterial cell lines. The group is equipped with a cell culture suite and has shared access to all the standard instrumentation required to conduct genetic engineering of cell lines, cell culture, and fermentation science. We collaborate closely with research groups that conduct in vivo studies in mouse and zebrafish models, and work in this area is possible according to the interests of the candidate. The position will involve supporting grant writing and working closely with the PI, Dr. John Trant. The position is also designed t oobtain rapid publication of multiple ongoing projects as well as establishing new projects within the group. The position will potentially also involve establishing new 3-d printed models of ex vivo constructs to study disease using the drugs designed and made by the group: the Trant Team is currently acquiring a state-of-the-art 3-D bioprinting suite. This is a leadership position within the group and the preferred candidate would either have held a leadership role during their PhD or have some postdoctoral experience.
This position is open to individuals holding a PhD in analytical chemistry or synthetic organic or inorganic chemistry with analytical chemistry expertise. The position will revolve around designing new methodologies to analyze nutraceticals and nutraceutical formulations, with a special focus on cannabinoids initially. This will involve microformualtion as well as HPLC, GC, DLS, DSC, TGA and NMR analysis of materials. It can also involve develping non-chromatographic separation strategies for complex mixtures. There will also be the potential to work with chemical engineers, materials scientists, and toxicologists on translating technology and developing new methods. The candidates will also, depending on interest and focus, be able to work with other members of the Trant Team on our research projects in whisky and wine science, cancer and autoimmune disease treatment, and supramolecular chemistry as their interests lead them. The industrial partners we are working with on these projects are fast-growing science and research and development-focused companies that would likely be looking to bring the expertise in-house following the fellowship while maintaining links with the University.
These are expected to start April-June 2020. Position is open to individuals holding a PhD in chemistry, biochemistry, molecular biology, or a related discipline. The successful candidate will have expertise in computational modelling of molecules. Preference for individuals with molecular modelling, molecular dynamics simulation experience in proteins and peptides. Ideally some experience with docking, QM/MM analysis using combinations of GROMACS, AMBER, Rosetta, Autodock Vina, the Schrodinger Suite, and Gaussian. Experience in bioinformatics is a large benefit but not necessary. The project will focus on an academic-research collaboration examining mechanism of action of small molecules with known and unknown protein targets. The candidates will also have the opportunity to work with structural biologists on crystallization, or with molecular biologists on protein expression and biophysics measurements. The candidates can also work in wet-lab synthetic chemistry or molecular biology associated with the project as they wish although this is not necessary.
Synthetic Chemistry, Natural Product Chemistry
These are expected to start April-June 2020. Position is open to individuals holding a PhD in chemistry or a related discipline. The successful candidate(s) will have expertise in either total synthesis, methodology development, medicinal chemsitry, or natural product isolation and identification chemistry. Preference will be given for individuals with experience in structural determination and/or process chemistry experience. Ideally the candidate will have experience with scale-up chemistry and non-chromatographic separation science (although HPLC experience is an asset). A strong understanding of organic mechanism and asymmetric synthesis is an asset. Science will involve developing new scalable synthetic and purification routes for complex materials. Individuals will be required to work closely with the biological, analytical and computational teams, and previous experience in an interdisciplinary environment, or a strong interest in developing this experience will be preferred (and will likely make you happier in the position).