Şimşek, İ; Shahbazi-Raz, F.; Krause, M. J.; Mohammadzadeh, A.; Kosar, M.; Xu, P.; Khan, S.; Tykhoniuk, O.; DaDalt, A.; Almasri, D.; Watanabe, L.;Breault, K.; Hayward, J. J.; Pick, F.; Ho, R.; Rawson, J.; Trant, J. F.* “A tale of two mechanisms: The p53 modulator COTI-2 is a Zn metallochaperone” Preprint submitted to ChemRxiv and available at: DOI: 26434/chemrxiv-2025-ffb6q.
Hosie, W. C.; Egbuta, M. A.; Razmkhah, K.; Bolandi, B.; Dehvari, K.; Homon, A.;Kappadakunnel, A., Simone, J. J.; Banerjee, A.*; Trant, J. F.* “Hemp proteins conjugated with green tea polyphenol extract form de novo plant-sourced emulsifiers suitable for nanodelivery systems bearing lipophilic psychopharmaceuticals” Preprint submitted to ChemRxiv and available at DOI: 26434/chemrxiv-2025-pjfn9.
Goel, A.; Negi, I.; Pandey, A. G.; Trant, J. F.*, Sharma, P.* “Mechanistic Insights into Cyclodipeptide Formation by Cyclodipeptide Synthases: A Preliminary Exploration on Pathways and Catalytic Residues” Available on ChemRxiv at DOI: 10.26434/chemrxiv-2024-79nfb.
Kosar, M; Abu-Saleh, A. A-A.; Awada, A.; Vu, S.; Rondeau-Gagné, S.*; Trant, J. F.* “Computational insights into the thermophysical, conformational and electronic properties of diketopyrrolopyrrole and isoindigo based semiconducting polymers” Available on ChemRxiv at: DOI: 10.26434/chemrxiv-2023-kk029.
Shahbazi, F.; Mohammadzadeh, S.; Meister, D.;Tararina, V.; Aggarwal, V.; Trant, J. F.* “Liver-Type Fatty Acid Binding Protein (FABP1) Has Exceptional Affinity for Minor Cannabinoids” Available on ChemRxiv at: DOI: 10.26434/chemrxiv-2023-82ztv.
Shahbazi, F.*; Meister, D.M.*; Mohammadzadeh, S.; Trant, J.F.* “How THC Works: Structural Insights Explaining Ligand Affinity for, and Partial Agonism of, Cannabinoid Receptor 1” ChemRxiv Preprint: 10.26434/chemrxiv-2023-mbr7t-v4
Meister, D.; Hayward, J.; Fifield, B.-A.; Porter, L. A.*; Trant, J. F.* “Spy1-activated Cyclin Dependent Kinase 2 Shows Reduced Affinity for Current Synthetic Small Molecule Inhibitors of the CDK2-Cyclin Complex” Available on ChemRxiv at: DOI: 10.26434/chemrxiv-2023-kzgfb
107. Ahmad, S.*; Pan, M.; Hayward, J. J.; Sementilli, M.; Porter, L. A.; Trant, J. F.* “Boron in my mind: A comprehensive review of the evolution and State-of-the-Art of the diverse syntheses of 4-borono-L-phenylalanine, the leading agent for boron neutron capture therapy” Preliminarily Accepted in ChemMedChem, February 24, 2025. Preprint submitted to ChemRxiv and available at: DOI: 10.26434/chemrxiv-2024-nstsf.
106. Ménard, A. D.*; Trant, J. F.* “Analysis of safety-related incidents reported at a major North American petrochemical processing facility between 2016 and 2020” ACS Chemical Health and Safety, 2025, Accepted February 4, 2025. DOI: https://doi.org/10.1021/acs.chas.4c00120.
105. Kone, E.†; Nasri, S.†; Parker, G. L.†; Desyatkin, V. G.; Martin, W. B.; Trant, J. F.*; Rodionov, V. O.* “Replication of mechanochemical syntheses of γ-graphyne from calcium carbide fails to produce the claimed product” Carbon, 2025, 232, 119808 (article number). DOI: 10.1016/j.carbon.2024.119808.
104. Jangra, R.; Trant, J.F.*, Sharma, P.* “Water-mediated ribonucleotide–amino acid pairs and higher order structures at the RNA–protein interface: Analysis of the crystal structure database and a topological classification” NAR Genomics and Bioinformatics, 2024, 6, lqae161 (article number). DOI: 10.1093/nargab/lqae161
103. Jangra, R.; Kukhta, T.; Sharma, P.*; Trant, J. F.* “Decoding the enigma of RNA-protein recognition: Quantum chemical insights into arginine fork motifs” Physical Chemistry Chemical Physics, 2024, 26, 28091-28100. DOI: 10.1039/D4CP03987D.
102. Iman, K.; Mirza, M. U.*; Daia, F.; Froeyen, M.; Trant, J. F.; Chaudhary, S. U. “Pharmacophore-assisted covalent docking identifies a potential covalent inhibitor for drug-resistant Genotype 3 variants of Hepatitis C Viral NS3/4A serine protease” Viruses 2024, 16, 1250 (article number) DOI: 10.3390/v16081250.
101. Grafinger, O. R. Hayward, J. J.; Meng, Y.; Geddes-McAlister, J.; Mar, S.; Sheng, M.; Su, B.; Thillainadesan, G.; Lipsman, N.; Coppolino, M. G; Trant, J. F.; Jerzak, K. J.; Leong, H. S.* “Cancer cell extravasation requires iplectin mediated choreography of MT1-MMP at invadopodia” British Journal of Cancer, 2024, 131, 931-943. DOI: 10.1038/s41416-024-02782-9.
100. Shahbazi-Raz, F.*; Egbuta, M.; Aremu, B. R.; Mashhadi, N.; Tucci, P.; Binder, J.; Trant, J. F.* “How impurities responsible for recalls emerge in hand sanitizers.” Accepted in RSC Sustainability 2024 (January 11). DOI: 10.1039/D3SU00286A
99. Ali, Z.; Kukhta, T.; Trant, J.F.*; Sharma, P.* “An Atlas of the base inter-RNA stacks involved in bacterial translation” Biophysical Chemistry 2024, 305, 107144 (Article Number) DOI: 10.1016/j.bpc.2023.107144
98. Naseem, S.; Khan. S.; Rauf, K.; Mirza, M. U.; Ashraf, M.; Trant, J. F.*; Shafiq, Z.* “Xanthene thiosemicarbazones as cholinesterase inhibitors” Accepted in Journal of Biomolecular Structure and Dynamics, 2023, October 18.
97. Cui, J.; Zhao, W.; Wu, J.; Zhang, D.; Liu, L.; Qiao, H.; Yan, Z.; Fu, Y.; Trant, J. F.*; Li, Y.* “Enhanced in vivo antitumor efficacy through the nanodiamond mediated co-delivery of drugs ” Accepted in the Journal of Drug Delivery Science and Technology, September 21, 2023.
96. Kosar, M.*; Taimoory, S. M.; Diesenhaus, O.; Trant, J. F.* “Electrolytes for Aluminum Ion Batteries: A Molecular Dynamics Study” 2023 Accepted in the Journal of Chemical Physics on September 20, 2023. ChemRxiv Preprint: 10.26434/chemrxiv-2022-fz69r
95. Shakourian-Fard, M.*; Ghenaatian, H. R.; Kamath, G.; Mjalli, F. S.; Trant, J.F.* “Adsorption behavior of boron nitride nanotubes and their boron and nitrogen vacancy defects towards deep eutectic solvents: A DFT study” Accepted in Chemical Physics Letters, August 29, 2023.
94. Banerjee, A.*; Aremu, B. R.; Dehghandokht, S.; Salama, R.; Zhou, H.; Lackie, S. M.; Seifi, M.; Kennepohl, P.; Trant, J.F.* “Lethal weapon IL: a nano-copper/tetraalkylphosphonium ionic liquid composite material with potent antibacterial activity” Accepted in RSC Sustainability, August 24, 2023. DOI: 10.1039/D3SU00203A.
93. Banerjee, A.; Hosie, W.; Terso Ventura, A. C.; Razmkhah, K.; Bautista, J.; Beyene, A.; Binder, J.; Trant, J. F.* “Rational design, synthesis, and characterization of a solid ∆9-tetrahydrocannabinol (THC) nanoformulation suitable for “microdosing” applications” Accepted in Cannabis and Cannabinoid Research, June 20, 2023. DOI: 10.1089/can.2023.0084
92. Ali, Z.; Kaur, S.; Kukhta, T.; Abu-Saleh, A. A.-A. A.; Jhunjhunwala, A.; Mitra, A.; Trant, J. F.*; Sharma, P.* “Structural mapping of the base stacks containing post transcriptionally modified bases in RNA” Journal of Physical Chemistry B, 2023, 127, 6049-6060. DOI: 10.1021/acs.jpcb.3c02268.
91. Noura, M.; Kosar, M.; Rahdar, A.*; Trant, J.F.* “Hydrogen adsorption on magnesium-decorated (3, 3) and (5, 0) boron nitride nanotubes” International Journal of Hydrogen Energy Accepted May 11, 2023. DOI: 10.1016/j.ijhydene.2023.05.117.
90. Ali, Z.; Kukhta, T.; Jhunjhunwala, A.; Trant, J. F.*; Sharma, P.* “Occurrence and classification of T-shaped interactions between nucleobases in RNA structures” Accepted in RNA, April 24, 2023. DOI: 10.1261/rna.079486.122.
89. Ahmad, S.; Mirza, U. M.*; Trant, J.F.* “Dockable aliphatic and cyclic tri, tetra and pentapeptide library generation: A systematic screening on SARS-CoV-2 main protease as a case study” Journal of Pharmaceutical Analysis, 2023, 13, 523-534. DOI: 10.1016/j.jpha.2023.04.008
88. Jonkergouw, C.; Beyeh, N.K.; Osmekhina, E.; Leskinen, K.; Taimoory, S.M.; Federov, D.; Anaya-Plaza, E.; Kostiainen, M. A.; Trant, J. F.; Ras, R.; Saavalainen, P.; Linder, M.* “Repurposing host-guest chemistry to sequester virulence and eradicate biofilms in multidrug resistant Pseudomonas aeruginosa and Acinetobacter baumannii” Nature Communications, 2023, 14, 2141. DOI: 10.1038/s41467-023-37749-6.
87. Saeed, S.; Ning, L.; Badreddine, A.; Mirza, M. U.; Boissel, M.; Khanam, R.; Manzoor, J.; Janjua, Q. M.; Khan, W. I.; Toussaint, B.; Vaillant, E.; Amanzougarene, S.; Canouil, M.; Derhourhi, M.; Trant, J. F.; Siegert, A.-M.; Lam, B. Y. H.; Yeo, G. S. H.; Chabraoui, L.; Touzani, A.; Farooqi, S. I.; Bonnefond, A.*; Arslan, M.*; Froguel, P.* “Biallelic mutations in P4HTM cause syndromic obesity” Diabetes 2023, 72, 1228-1234. DOI: 10.2337/db22-1017.
86. Banerjee, A. R.; Hayward, J. J.; Trant, J. F.* “Breaking bud: The effect of direct chemical modifications of phytocannabinoids on their bioavailability, physiological effects, and therapeutic potential” Organic and Biomolecular Chemistry, 2023, 21, 3715-3732. DOI: 10.1039/D3OB00068K. Cover Image: 10.1039/D3OB90071A.
85. Twum, K.; Nadimi, S.; Osei, F. B.; Puttreddy, R.; Ojong, Y. B.; Hayward, J. J.; Rissanen, K.; Trant, J. F.; Beyeh, N. K.* “The “nitrogen effect”: Complexation with macrocycles potentiates fused heterocycles to form halogen bonds in competitive solvents” Chemistry – An Asian Journal, 2023, 18 (6), e202201308 (article number). DOI: 10.1002/asia.202201308.
84. Ali, Z.; Goyal, A.; Jhunjhunwala, A.; Mitra, A.; Trant, J. F.*; Sharma, P.* “Structural and energetic features of base-base stacking contacts in RNA” The Journal of Chemical Information and Modeling, 2023, 63, 655-669. DOI: 10.1021/acs.jcim.2c01116.
83. Negi, I.; Jangra, R.; Gharu, A.; Trant, J. F.*; Sharma, P.* “Guanidinium–amino acid hydrogen-bonding interactions in protein crystal structures: Implications for guanidinium-induced protein denaturation” Physical Chemistry Chemical Physics, 2023, 25, 857-869. DOI: 10.1039/D2CP04943K.
82. Wu, J.; Du, X.; Zhang, D.; Cui, J.; Zhang, X.; Duan, X.; Trant, J. F.*, Li, T.* “A nanodiamond chemotherapeutic folate receptor-targeting prodrug with triggerable drug release” International Journal of Pharmaceutics, 2023, 630, 122432 (article number) DOI: 10.1016/j.ijpharm.2022.122432
81. Taimoory, S.M.*; Yu, X.; Beyeh, N. K.; Nasri, S.; Trant, J.F.* “Highly optically responsive divalent benzimidazolium-based axles with pseudorotaxane potential” Journal of Organic Chemistry, 2022, 87, 15783-15795. DOI: 10.1021/acs.joc.2c01758.
80. Saleeem, T.; Khan, S.; Yaqub, M.; Khalid, M.; Islam, M.; Yousaf ur Rehman, M.; Rashid, M.; Shafiq, I.; Braga, A.; Syed, A.; Bahkali, A.; Trant, J. F.; Shafiq, Z.* “Novel quinoline-derived chemosensors: Synthesis, anion recognition, spectroscopic and computational study” New Journal of Chemistry 2022, 46, 18233-18243 DOI: 10.1039/D2NJ02666J.
79. Mader, L.; Hayward, J. J.*; Porter, L. A.; Trant, J.F.* “A revised synthesis of 6-alkoxy-2-aminopurines with late-stage convergence allowing for increased molecular complexity” New Journal of Chemistry 2022, 46, 17040-17048, DOI: 10.1039/D2NJ02204D
78. Cataldo, V. A.; Taimoory, S. M.; Mohammadzadeh, S.; Guterman, R.*; Trant, J.F.* “A solid alkylation: Highly recyclable, flow chemistry-ready, resin-supported thioimidazoliums alkylate sulfur-centered nucleophiles” the European Journal of Organic Chemistry, 2022, (35), Article number: e202200367 DOI: 10.1002/ejoc.202200367
77. Ghenaatian, H. R.*; Shakourian-Fard, M.; Kamath, G.; Trant, J.F.; Mialli, F. S. “The Interaction of Deep Eutectic Solvents with Pristine and Defective Carbon Nanotubes: A Density Functional Theory Study” Journal of Molecular Liquids, 2022, 119855. DOI: 10.1016/j.molliq.2022.119855
76. Sadraei, S. I.; Yousif, G.; Taimoory, S. M.; Kosar, M.; Mehri, S.; Alolabi, R.; Igbokwe, E.; Toma, J.; Rahim, M.*; Trant, J. F.*, “The total synthesis of glycolipids from S. pneumoniae and a re-evaluation of their immunological activity”. ChemBioChem 2022, 23, (18), Article Number: e202200361 DOI: 10.1002/cbic.202200361.
75. Twum, K.; Truong, K.-N.; Osei, F. B.; Von essen, C.; Nadimi, S.; Trant, J.F.; Rissanen, K.; Beyeh, N. K.* “Guest-mediated self-assembly of deprotonated 2-bromoresorcinarenes” Crystal Growth and Design, 2023, 23 (2), 1281-1287. DOI: 10.1021/acs.cgd.2c00325
74. Mirza, M.U.; Alanko, I.; Vanmeert, M.; Muzzarelli, K. M.; Salo-Ahen, O. M. H.; Abdullah, I.; Kovari, I. A.; Claes, S.; De Jonghe, S.; Schols, D.; Schinazi, R. F.; Kovari, L. C.; Trant, J. F.; Ahmad, S.; Froeyen, M.* “The discovery of Zika virus NS2B-NS3 inhibitors with antiviral activity via an integrated virtual screening approach” European Journal of Pharmaceutical Sciences 2022, 175, 106220 (article number) DOI: 10.1016/j.ejps.2022.106220
73. Karle, A.; Twum, K.; Sabbagh, N.; Haddad, A.; Taimoory, S.M.; Szczęśniak, M. M.; Trivedi, E.; Trant, J.F.; Beyeh, N.K.* “Naphthalene-Functionalized Resorcinarene as Selective, Fluorescent Self-Quenching Sensor for Kynurenic Acid” Analyst, 2022, 147, 2264. DOI: 10.1039/d1an02224e
72. Hayward, J.J.*; Mader, L.; Trant, J.F.* “Giving preparative TLC some tender loving care” Synthesis, 2022, 54(10): 2391-2394. DOI: https://doi.org/10.1055/a-1766-2416
71. Twum, K.; Sadraei, S. I.; Feder, J.; Taimoory, S.M.*; Rissanen, K.*; Trant, J.F.*; Beyeh, N. K.* “Sharing the salt bowl: Counterion identity drives N-alkyl resorcinarene affinity for pyrophosphate in water” Organic Chemistry Frontiers, 2022, 9, 1267-1275. DOI: 10.1039/D1QO01877A
70. , M.K; , D.; , L.A*.; Trant, J.F.* “Identification of alternative protein targets of glutamate-ureido-lysine associated with PSMA tracer uptake in prostate cancer cells” 2022, PNAS, 119 (4) e2025710119 DOI: 10.1073/pnas.2025710119
69. St. Onge, B.; Taimoory, S.M.; Battersby, J.; Trant, J.F.*; Green, J. R.* “Reaction of Alkynyl- and Alkenyltrifluoroborates with Propargyldicobalt Cations. Alkynylation, Alkenylation and Cyclopropanation Product Pathways” Journal of Organic Chemistry. 2021, 86, 24, 18094–18106. DOI: 10.1021/acs.joc.1c02352.
68. Shakourian-Fard, M.*; Taimoory, S.M.; Ghenaatian, H. R.; Kamath, G.; Trant, J.F.* “Effect of mono-vacant defects on the adsorption properties of deep eutectic solvents onto hexagonal boron nitride nanoflakes” Journal of Molecular Liquids 2022, 349, 118122 (article number) DOI: 10.1016/j.molliq.2021.118122
67. Ménard, A.D.*; Flynn, E.; Soucie, K.; Trant, J.F. “Accident experiences and reporting practices in Canadian chemistry and biochemistry labs: A pilot investigation” ACS Chemical Health and Safety 2022, 29, 1, 102–109. DOI: 10.1021/acs.chas.1c00070
66. Vu, S.; Nagesh, G.; Yousefi, N.; Trant, J.F., Ting, D. S.-K.; Ahamed, J.*; Rondeau-Gagné, S.* “Fabrication of an autonomously self-healing flexible thin-film capacitor by slot-die coating” Material Advances 2021 2, 6676-6683. DOI: 10.1039/D1MA00656H
65. Piazza, S.$; Reynolds, M. R.$; Chiaramonte, J.; Xu, PeiHan; Chapa Villarreal, F.; Trant, J.F.* “Efficient and Reproducible Synthesis of an Fmoc-protected Tn Antigen.” New Journal of Chemistry, 2021, 45, 19224-19227 DOI: 10.1039/D1NJ01173A.
$: Co-first authors, and the names can be interchanged in order for any professional purpose.
64. Banerjee, A.; Binder, J.; Salama, R.; Trant, J.F.* “Synthesis, characterization and stress-testing of a novel quillaja saponin stabilized oil-in-water phytocannabinoid nanoemulsion” the Journal of Cannabis Research, 2021, 23;3(1):43, DOI: 10.1186/s42238-021-00094-w
63. Aremu, O.S.*; Qwebani-Ogunleye, T.; Katata-Seru, L.; Mkhize, Z.; Trant, J.F.* “Synergistic broad-spectrum antibacterial activity of Hypoxis hemerocallidea-derived silver nanoparticles and streptomycin against respiratory pathobionts” Scientific Reports 11, 2021, 15222 (2021) (article number) DOI: 10.1038/s41598-021-93978-z
62. Knezevic, S.; Ghafoor, A.; Mehri, S.; Barazi, A.; Dziura, M.;Trant, J.F.*; Dieni, C.A.*“Catechin and other catechol-containing secondary metabolites: Bacterial biotransformation and regulation of carbohydrate metabolism” PharmaNutrition, 2021, 100273. DOI: 10.1016/j.phanu.2021.100273.
61. Ahmad, S.*; Mirza, M. U.; Kee, L. Y.; Nazir, M.; Abd Rahman, N.; Trant, J.F.; Abdullah, I. “Fragment-based in silico design of SARS CoV-2 main protease inhibitors” Chemical Biology & Drug Design. 2021,98(4):604-619, DOI: 10.1111/cbdd.13914
60. Naheed, N.; Khan, A.; Wadood, A.; Maher, S.; Rahseed, S.; Saleem, F.; Choudhary, M. I.; Froyen M.; Abdullah, I.; Mirza, M. U.; Trant, J. F.; Ahmad, S.* “New isolate from Salvinia molesta with antioxidant and urease inhibitory activity” Drug Development Research. 2021, Volume82, Issue8, Pages 1169-1181. DOI: 10.1002/ddr.21831
59. Wang, H.; Vu, S.; Pignanelli, J.; Fatah, T. A.; Trant, J. F.; Mahshid, S.; Rondeau-Gagné, S.*; Ahamed, M. J.* “Fabrication and Characterization of Autonomously Self-Healable and Stretchable Soft Microfluidics” Advanced Sustainable Systems 2021, 6 (2), Article Number 2100074. DOI: 10.1002/adsu.202100074.
58. Reynolds, M.R.; Pick, F.; Hayward, J.J.*; Trant, J.F.* “Methyl 2-carboxyresorcinarene” Symmetry 2021, 13(4), 627 DOI: 10.3390/sym13040627
57. Wen, X.; Wen, G.; Li, W.; Zhao, Z.; Duan, X.; Yan, W.; Trant, J.F.* Li, Y* “High Yield Fluorescent Carbon Dots: Specific “Off-On” Sensing of Co2+ and EDTA, Bioimaging, and Metabolism in vivo” Materials Science and Engineering C, 2021, 123, 112022 (Article Number). DOI: 10.1016/j.msec.2021.112022.
56.Tahir, N.; Shahbazi, F.; Rondeau-Gagné, S.*; Trant, J.F.* “The Biosynthesis of the Cannabinoids” Journal of Cannabis Research 2021, 3, 7 (Article Number) DOI: 10.1186/s42238-021-00062-4.
55. Pérez-Escalante, E., González-Olivares, L. G.; Castañeda-Ovando, A.; Cruz-Guerrero, A. E.; Trant, J.F.; Lopez-Orozco, W.; Mendoza-Huizar, L.H.*; Alatorre-Santamaría, S.* “An In Silico Approach to Enzymatic Synthesis of Fucooligosaccharides Using α-L-Fucosidase from Thermotoga maritime” Chemistry Proceedings 2020, 3 (1), 10. DOI: 10.3390/ecsoc-24-08303
54. Shakourian-Fard, M.*; Taimoory, S.M.*; Ghenaatian, H.R.; Kamath, G.; Trant, J.F.* “A DFT Study of the Adsorption of Deep Eutectic Solvents onto Graphene and Defective Graphene Nanoflakes” Journal of Molecular Liquids,Vol. 327, 2020, 114850. DOI: 10.1016/j.molliq.2020.114850
53. Li, W.; Zhao, H.; Wen, X.; Yan, W. Trant, J.F.*, Li, Y Acid-Triggered Self-Assembled Egg White Protein-Coated Gold Nanoclusters for Selective Fluorescent Detection of Fe3+, NO2-, and Cysteine” ACS Appl. Nano Mater. 2020, 3, 12, 11838–11849. DOI: 10.1021/acsanm.0c02358
52. Taimoory, S.M.; Cataldo, V.A.; Schäfer, A.; Trant, J.F.*; Guterman, R.* “Not-so-innocent anions determine the mechanism of cationic alkylators”Chemistry – a European Journal, 2021. DOI: 10.1002/chem.202004208
51. Askari, F.; Rahdar, A.*; Dashti, M.; Trant, J.F.* “Detecting mercury (II) and thiocyanate using “turn-on” fluorescence of graphene quantum dots” the Journal of Fluorescence, 2020, 30, pages 1181–1187. DOI: 10.1007/s10895-020-02586-z
50. Shahbazi, F.; Grandi, V.; Banerjee, A.; Trant, J. F.*, “Cannabinoids and cannabinoid receptors: The story so far” iScience 2020, 101301. DOI: https://doi.org/10.1016/j.isci.2020.101301
49. Rahdar, A.*; Hajinezhad, M. R.*; Nasri, S.; Beyzaei, H.; Barani, M.; Trant, J. F.*, “The synthesis of methotrexate-loaded F127 microemulsions and their in vivo toxicity in a rat model” Journal of Molecular Liquids, 2020, 313, 113449. DOI: https://doi.org/10.1016/j.molliq.2020.113449
48. Puttreddy, R.; Taimoory, S.M.; Dashti, M.; Twum, K.; Pan, F.; Rissanen, K.*; Trant, J.F.*; Beyeh, N.K.* “Bringing a Molecular Plus One: Synergistic Binding Creates Guest-Mediated Three Component Complexes” the Journal of Organic Chemistry, March 16, 2020. 85, 5884-5894. DOI: 10.1021/acs.joc.0c00220
47. Noura, M.; Rahdar, A.*; Taimoory, S.M.; Hayward, J.J.; Sadraei, S.I.; Trant, J.F.* “Effect of aluminium-doped boron-nitride nanotube architecture on hydrogen adsorption: A first-principles DFT examination” the International Journal of Hydrogen Energy, 2020, 45, 11176-11189 DOI: 10.1016/j.ijhydene.2020.02.053
46. Pérez-Escalante, E., González-Olivares, L. G.; Castañeda-Ovando, A.; Salazar-Pereda, V.; Trant, J.F.; Bautista-Ávila, M.; Alatorre-Santamaría, S.* “Green, microwave-assisted synthesis of O-perbutirylated-alkyl-glycosides” Proceedings, 2020, 41, 42 DOI: 10.3390/ecsoc-23-06500.
45. Ménard, A.D.*; Trant, J.F.* “Academic lab safety: A narrative review and call for action” Nature Chemistry 2020, 12, 17-25. DOI:10.1038/s41557-019-0375-x.
FREE LINK FOR EVER (Read only online, not printable) Thanks Nature Chem!
44. Rahdar, A.*; Beyzaei, H.; Saadat, M.; Yu, X.; Trant, J.F.* “Synthesis, physical characterization, antifungal and antibacterial activity of oleic acid-capped nanomagnetite and cobalt-doped nanomagnetite” Canadian Journal of Chemistry 2020, 98, 34-39. DOI: 10.1139/cjc-2019-0268
43. Meister, D.; Ure, D.; Awada, A.; Mutus, B.*; Trant, J.F.* “Covalently Functionalized Sawdust for the Remediation of Phosphate from Agricultural Wastewater” Accepted ACS Sustain. Chem. Eng. 2019, 7, 20139-20150. 10.1021/acssuschemeng.9b06073
42. Bakht, M. K.; Lovnicki, J.M.; Tubman, J.; Stringer, K.F.; Chiaramonte, J.; Reynolds, M.R.; Derecichei, I.; Ferraiuolo, R.-M.; Fifield, B.-A.; Lubanska, D.; Oh, S. W.; Cheon*, G. J.; Kwak, C.; Jeong, C.W.; Kang, K. W.; Trant, J.F.; Morrissey, C.; Coleman, I.M.; Wang, Y.; Ahmadzadehfar, H.*; Dong, X.; Porter, L. A.* “Differential gene expression of glucose transporters and hexokinases in PSMA suppressed prostate cancers with neuroendocrine and double negative gene signatures is associated with higher glucose uptake” Journal of Nuclear Medicine, 2020, 61, 904-910. DOI: 10.2967/jnumed.119.231068
41. Ferraiuolo, R.-M.; Meister, D.; Leckie, D.; Dashti, M.; Franke, J.; Porter, L.A.*; Trant, J.F.* “Neuro and hepatic toxicological profile of (S)-2,4-diaminobutyric acid in embryonic, adolescent and adult zebrafish” Accepted to Journal of Applied Toxicology, 2019, 39, 1568-1577. DOI: 10.1002/jat.3840
40. Shakourian-Fard,* M.; Kamath, G.; Taimoory, S.M.; Trant, J.F.* “Calcium-ion batteries: Identifying ideal electrolytes for next generation energy storage using computational analysis” Journal of Physical Chemistry C, 2019, 123, 15885-15896. DOI: 10.1021/acs.jpcc.9b01655
39. Pan, F.*; Dashti, M.; Reynolds, M.R.; Rissanen, K.; Trant, J.F.*; Beyeh, N.K.* “Halogen bonding and host-guest chemistry between N-alkyl ammonium resorcinarene halides, diiodoperfluorobutane and neutral guests” Beilstein Journal of Organic Chemistry, 2019, 15, 947-954. (Invited) DOI: 10.3762/bjoc.15.91
38. Rahdar, S.; Rahdar, A.; Ahmadi, S.; Trant, J.F.* “Adsorption of bovine serum albumin (BSA) by bare magnetite nanoparticles with surface oxidative impurities that prevent aggregation” Canadian Journal of Chemistry, 2019, 97, 577-583. 10.1139/cjc-2019-0008.
37. Askari, F.; Rahdar, A.*; Trant, J.F.* “Cysteine-functionalized quantum dots are fluorescent sensors able to discriminate between the enantiomers of tryptophan” Sensing and Bio-Sensing Research, 2019, 22, 100251 https://doi.org/10.1016/j.sbsr.2018.100251. (Open Access courtesy of Elsevier).
24058
36. Meister, D.; Taimoory, S.M.; Trant, J.F.* “Synthetic amino acids for the treatment of MHC Type II diseases history and perspectives” Peptide Science, 2018, 111 (1), e24058. Special issue celebrating 150 years of Canadian peptide science. (Invited). DOI: 10.1002/pep2.24058 COVER PICTURE! OPEN ACCESS ALL OF 2019 THANKS TO WILEY AND THE AMERICAN PEPTIDE SOCIETY!
35. Shakourian-Fard, M.*; Taimoory, S. M.*; Semeniuchenko, V.; Kamath, G.; Trant, J.F.* “The Effect of Ionic Liquid Adsorption on the Electronic and Optical Properties of Fluorographene Nanosheets” Journal of Molecular Liquids, 2018, 268, 206-214. DOI: 10.1016/j.molliq.2018.07.054.
33. Puttreddy, R.; Beyeh, N.K.; Taimoory, S. M.; Meister, D.; Trant, J.F.*; Rissanen, K.* “Host-Guest Complexes of Conformationally Flexible C-hexyl-2-Bromoresorcinarene and Aromatic N-oxides: Solid-state, Solution and Computational Studies” Beilstein Journal of Organic Chemistry, 2018, 14, 1723-1733. DOI: 10.3762/bjoc.14.146. (Invited)
32. Taimoory, S. M.; Rahdar, A.*; Aliahmad, M.*; Sadeghfar, F.; Hajinezhad, M.R.; Jahantigh, M.; Shahbazi, P.; Trant, J. F.*, “The synthesis and characterization of a nanomagnetite with potent antibacterial activity and low mammalian toxicity” Journal of Molecular Liquids 2018, 265, 96-104. DOI: 10.1016/j.molliq.2018.05.105.
29. Taimoory, S. M.; Sadraei, S. I.; Fayoumi, R.; Nasri, S.; Revington, M.; Trant, J. F.* “Preparation and Characterization of a Small Library of Thermally-Labile End-Caps for Variable-Temperature Triggering of Self-Immolative Polymers” Journal of Organic Chemistry 2018, 83, 4427-4440. DOI: 10.1021/acs.joc.8b00135
28. Sadraei, S.I.; St-Onge, B.; Trant, J.F.* “Recent Advances in the Application of Carbohydrates as Renewable Feedstocks for the Synthesis of Nitrogen-Containing Compounds” Chapter in: Green Chemical Processes, Advances in Education. DeGruyter, 2018. Accepted and In Press. (Invited). DOI: 10.1515/psr-2018-0074
27. Smith, L.J.; Taimoory, S.M.; Tam, R.Y.; Baker, A.E.G.; Binth Mohammad, N.; Trant, J.F.*, Shoichet, M.S.* “Diels-Alder Click-Crosslinked Hydrogels with Increased Reactivity Enable 3D Cell Encapsulation” Biomacromolecules, 2018, 19, 926-935. DOI: 10.1021/acs.biomac.7b01715.
26. Beyeh, N.K.*; Díez, I.; Taimoory, S.M.; Meister, D.; Feig, A.; Trant, J.F.*; Ras, R.H.A.*; Rissanen, K.* “High-affinity and selective detection of pyrophosphate in water by a resorcinarene salt receptor” Chemical Science, 2018, 9, 1358-1367. DOI: 10.1039/C7SC05167K .
25. Turunen, L.; Pan, F.*; Beyeh, N.K.*; Trant, J.F.; Ras, R.H.A.; Rissanen, K.* “Bamboo-like Chained Cavities and Other Halogen-Bonded Complexes from Tetrahaloethynyl Cavitands with Simple Ditopic Halogen Bond Acceptors” Crystal Growth and Design, 2018, 18, 513-520. DOI: 10.1021/acs.cgd.7b01517 (Invited)
24. Puttreddy, R.; Beyeh, N.K.; Jurcek, P.; Turunen, L.; Trant, J.F.; Ras, R.H.A.; Rissanen, K.* “Host-guest complexes of C-propyl-2-bromoresorcinarene with aromatice-N-oxides” Supramolecular Chemistry, 2018, 30, 445-454. DOI: 10.1080/10610278.2017.1414217.
23. Sadraei, S. I.; Reynolds, M. R.; Trant, J.F.* “The synthesis and biological characterization of acetal-free mimics of the tumour-associated carbohydrate antigens” Advances in Carbohydrate Chemistry and Biochemistry, 2017, 74, 137-237. DOI: 10.1016/bs.accb.2017.10.003.
21. Turunen, L.; Pan, F.; Beyeh, N. K.; Raatikainen, K.; Trant, J. F.; Ras, R.H.A.; Rissanen, K.*, “Halogen-bonded solvates of tetrahaloethynyl cavitands” CrystEngComm 2017, 19, 5223-5229. DOI: 10.1039/C7CE01118K.
20. Puttreddy, R.; Beyeh, N. K.; Ras, R. H. A.; Trant, J. F.; Rissanen, K.*, “Endo-/exo– and halogen-bonded complexes of conformationally rigid C-ethyl-2-bromoresorcinarene and aromatic N-oxides” CrystEngComm 2017, 19, 4312-4320. DOI: 10.1039/C7CE00975E.
19. Taimoory, S. M.; Rahdar, A.; Aliahmad, M.; Sadeghfar, F.; Hashemzaei, M.; Trant, J. F.*, “Importance of the inter-electrode distance for the electrochemical synthesis of magnetite nanoparticles: synthesis, characterization, and cytotoxicity” e-Journal of Surface Science and Nanotechnology 2017, 15, 31-39. DOI: 10.1380/ejssnt.2017.31.
Trant Team Patents!
Issued
4. Trant, J.F.; Taimoory, S.M.; Dashti, M.; Nasri, S.; Meister, D.; Hayward, J.J.; Chifor, A. “Thermally Sensitive Protecting Groups for Cysteine, and Manufacture and Use Thereof” US patent: 2022024942A1; Published February 11, 2021; Canadian patent CA3089634, Published February 6, 2021.
Provisional and Full Applications
25 Trant, J. F.; Dehvari, K.; Razmkhah, K.; Hosie, W. C.; Egbuta, M.; Hayward, J. J. “Mushroom tincture-based neuroactive drug delivery systems” US provisional patent application # 63/760,865. Filed February 20, 2025
24 Trant, J. F.; Dehvari, K.; Razmkhah, K.; Hosie, W. C.; Egbuta, M. “Neuroactive Delivery by Pickering Emulsion Micro/Nanoformulation” US provisional patent application # 63/760,858. Filed February 20, 2025
23 Trant, J. F.; Dehvari, K.; Razmkhah, K.; Hosie, W. C.; Egbuta, M. “Neuroactive Delivery by Protein Nanocarrier” US provisional patent application # 63/760,853. Filed February 20, 2025
22 Trant, J. F.; Razmkhah, K.; Dehvari, K.; Hosie, W. C “Neuroactive Delivery by Niosome Nanoformulation for Improved Blood-Brain-Barrier Penetration” US provisional patent application # 63/760,846. Filed February 20, 2025
21 Trant, J. F.; Hosie, W. C.; Banerjee, A. R.; Dehvari, K.; Razmkhah, K.; Egbuta, M. “Modifications of solid lipid nanoparticle based nanoformulations for enhanced psychedelic drug delivery” US provisional patent application # 63/734,886. Filed February 20, 2025
20 Trant, J. F.; Hosie, W. C.; Banerjee, A. R.; Dehvari, K.; Razmkhah, K.; Egbuta, M. “A self-nanoemulsifying drug delivery system (SNEDDS) optimized for intranasal administration bearing a tryptamine psychedelic payload” US provisional patent application #63/760,828. Filed February 20, 2025
19 Trant, J.F.; Homon, A.; Laramie, J.; Hayward, J. J. “A New Route to both Bufotenine and 5-Methoxydimethyl tryptamine and their Analogs and Derivatives” WIPO patent filed, February 7, 2025. Filing number pending.
18 Trant, J.F.; Hosie, W. C.; Banerjee, A. R.; Razmkhah, K.; Egbuta, M. A.; “Plant protein-green tea polyphenol conjugates as emulsifiers” WIPO patent filed, February 7, 2025. Filing number pending.
17 Trant, J. F.; Abu-Saleh, A. A-A. A. A.; Mirza, M. U. “Next generation phenethylamine-based 5-HT2AR agonists” US patent application #19/039,590. Filed January 28, 2025
16 Trant, J.F.; Razmkhah, K.; Banerjee, A. R.; Egbuta, M. A.; Mansouri, M.; Simone, J. J. “Encapsulated mushroom extract powder materials using a spray drier” US and Canada patent application # PCT/CA2024/051705. Filed December 19, 2024.
15 Trant, J.F.; Razmkhah, K.; Banerjee, A. R.; Egbuta, M. A.; Al-Shabi, M.; Mansouri, M.; Simone, J. J. “Encapsulated mushroom extract powder materials using lyophilization” US and Canada patent application # PCT/CA2024/051704. Filed December 19, 2024.
14 Trant, J. F. Hayward, J. J.; Homon, A.; Banerjee A. R. Simone, J. “Lipidic Nano-Pharmaceuticals” US patent application # 18/394,960. Filed December 22, 2023.
13 Trant, J. F. Abu-Saleh, A. A. A.; Mirza. M. U. Simone, J. “Next generation 5-HT2AR agonists” US patent application # 18/394,960. Filed December 22, 2023.
12 Trant, J.F.; Abu-Saleh, A. A. A.; Mirza. M. U. “Next generation phenethylamine-based 5-HT2AR agonists” US provisional patent application #63/622,747. Filed January 22, 2024.
11 Trant, J. F.; Nasri, S.; Hayward, J. J. “A general solid-phase synthesis of Crown Ethers” US patent application 18/678589 Filed May 23, 2024
10 Trant, J. F.; Porter, L.A.; Fifield, B.-A.; Meister, D.; Hayward, J.; Mader, L.; Secara, T.; “Unique and Selective Targeting of CDK Activity in Aggressive Carcinomas” US provisional patent application #63/580,052 Filed September 1, 2023
9. Trant, J. F.; Banerjee, A. R.; Aremu, A. R.; Dehghandokht, S. “Antimicrobial Material Comprising a Tetraalkylphosphonium Ionic Liquid and Metal Nanoparticles” US provisional patent application #63/504,227 Filed May 25, 2023
8. Trant, J.F.; Simone, J.; Banerjee, A.; Hayward, J.J. “Lipid nano-pharmaceuticals” US provisional patent application #63/434,697 Filed December 22, 2022
7. Trant, J. F.; Aziz, A.A.; Mirza, M.U.; Simone, J. “Design and synthesis of next generation tryptamine, phenethylamine and related 5-HT2AR agonists” US provisional patent application #63/434,994 Filed December 22, 2022
6. Trant, J.F.; Banerjee, A.; Simone, J. “Nano and micro-formulations of mushroom and plant derived psychedelic and non-psychedelic health materials” US provisional patent application #63/437,448 Filed January 6, 2023
5. Binder, J. F.; Banerjee, A.; Patel, K. K.; Scott, I.; Trant J. F. “Water-dispersible cannabinoid emulsion formulations, methods of making and applications” US provisional patent application # 63/373,915. Filed August 30, 2022.
Before the Trant Team
3. Ragogna, P.; Gillies, E.R.; Cuthbert, T.; Trant, J.F. “Increasing the hydrophilicity of phosphonium polymers to increase antibacterial activity and decrease hemolytic activity” US Provisional patent: #62/511,821
2. 2014 Gillies, E.R.; Fan, B.; Trant, J.F.; Wong, A. “Stimuli-responsive polyglyoxylates as biodegradable polymers” US Provisional patent 61/989,089.
1. 2014 Gillies, E.R.; Ferrari, L.; McEachran, M.; Trant, J.F.; Sran, I. “Polymer-Drug Conjugate Based on a Polyisoolefin-Based Copolymer” European patent application EP141956653.
34. Cuthbert, T.J.; Hisey, B.; Harrison, T.D.; Trant, J.F., Gillies, E.R.; Ragogna, P.J.* “Surprising Antibacterial Activity and Selectivity of Hydrophilic Polyphosphoniums Featuring Sugar and Hydroxyl Substituents” Angewandte Chemie International Edition, 2018, 57, 12707-12710. VIP Paper (Top 5% importance of those published in ACIE as determined by editor). DOI: 10.1002/anie.201806412
31. Badilov, D.; Rycek, L.; Trant, J.F.; Froese, J.; Murphy, B.; Hudlicky, T.* “Chemoenzymatic Approach to Tetrodotoxin: Synthesis of Fukuyama’s, Alonso’s, and Sato’s Advanced Intermediates” Angewandte Chemie International Edition, 2018, 57, 10994-10998. VIP PAPER (Top 5% importance of those published in ACIE as determined by editor). DOI: 10.1002/anie.201804602 COVER PICTURE!!!
30. Fan, B.; Yardley, R.E.; Trant, J.F.; Borecki, A.; Gillies, E.R.*, “Tuning the hydrophobic cores of self-immolative polyglyoxylate assemblies” Polymer Chemistry, 2018, 9, 2601-2610. DOI: 10.1039/C8PY00350E
22. Fan, B.; Trant, J. F.; Hemery, G.; Sandre, O.; Gillies, E. R.*, “Thermo-Responsive Self-Immolative Nanoassemblies: Direct and Indirect Triggering.” Chemical Communications (Cambridge) 2017, 53, 12068-12071. DOI: 10.1039/c7cc06410a COVER PICTURE!
18. Fan, B.; Trant, J. F.; Gillies, E. R.*, “End-capping strategies for triggering end-to-end depolymerization of polyglyoxylates” Macromolecules 2016, 49 (24), 9309-9319. DOI: 10.1021/acs.macromol.6b02320.
17. Trant, J.F.; Jain, N.; Mazzuca, D.M.; McIntosh, J.T.; Haeryfar, S.M.M.; Lecommandoux, S.; Gillies, E.R.* “Synthesis, self-assembly, and immunological bioactivity of α-galactose-functionalized dendron-lipid amphiphiles.” Nanoscale, 2016, 8, 17694-17704. DOI: 10.1039/c6nr05030a.
16 .Fan, Bo; Trant, J.F.; Yardley, R.; Pickering, A.; Lagugne-Labarthet, F.; Gillies, E.R.* “Photocontrolled degradation of stimuli-responsive poly(ethyl glyoxylate): Differentiating features and traceless ambient depolymerization” Macromolecules, 2016, 49, 7196-7203. DOI: 10.1021/acs.macromol.6b01620.
15. Naoum, R.; Séguin, J.P.; Trant, J.F.; Frampton, M.; Hudlicky, T.; Zelisko, P.M.* “A Chemoenzymatic Route to Chiral Siloxanes: A Step Towards the Enzymatic Synthesis of Chiral Silicone Polymers” Tetrahedron, 2016, 72, 4027-4031. DOI: 10.1016/j.tet.2016.05.032.
14. Trant, J. F.; Abd Rabo Moustafa, M. M.; Sran, I.; Gillies, E. R.* “Polyisobutylene-paclitaxel conjugates with pendant carboxylic acids and polystyrene chains: Towards multifunctional stent coatings with slow drug release.” Journal of Polymer Science Part A: Polymer Chemistry, 2016, 54, 2209-2219. DOI: 10.1002/pola.28094.
13. Peyret, A.; Trant, J.F.; Bonduelle, C.V.; Jain, N.; Lecommandoux, S.; Gillies, E.R.* “Synthetic glycopolypeptides: Synthesis and Self-Assembly of Poly(γ-benzyl-L-glutamate)-Glycosylated Dendron Hybrids.” Polymer Chemistry, 2015, 6, 7902-7912. DOI: 10.1039/C5PY01060H.
12. Trant, J. F.; Sran, I.; de Bruyn, J. R.; Ingratta, M.; Borecki, A.; Gillies, E. R.* “Synthesis and Properties of Arborescent Polyisobutylene Derivatives and a Paclitaxel Conjugate: Towards Stent Coatings with Prolonged Drug Release” European Polymer Journal 2015, 72, 148-162. DOI: 10.1016/j.eurpolymj.2015.09.012.
11. Trant, J.F.; Sran, I.; McEachran, M.; Turowec, B.; de Bruyn, J.R.; Gillies, E.R.* “Covalent polyisobutylene-paclitaxel conjugates for controlled release from potential vascular stent coatings.” ACS Applied Materials and Interfaces 2015, 7, 14506-14517. DOI: 10.1021/acsami.5b04001.
10. McEachran, M. J.; Trant, J. F.; Sran, I.; de Bruyn, J. R.; Gillies, E. R.* “Carboxylic acid functionalized butyl rubber: synthesis, characterization and physical properties.” Industrial & Engineering Chemistry Research 2015, 54, 4763-4772. DOI: 10.1021/acs.iecr.5b00421.
9. Fan, B., Trant, J.F., Wong, A.D., Gillies E.R.* “Polyglyoxylates: A versatile class of triggerable self-immolative polymers from readily accessible monomers.” Journal of the American Chemical Society, 2014, 136, 10116-10123. DOI: 10.1021/ja504727u
8. Trant, J.F., Ho, H., Hudlicky, T.* “The Chiro-Inositols and related cyclitols as chiral monomers for polymerization: Expansion of a family of chiral polymers” Synlett, 2014, 25, 2360-2364. DOI: 10.1055/s-0034-1378563
7. Trant, J.F.; Froese, J.; Hudlicky, T.* “Enzymatic oxidation of para-substituted arenes: access to new non-racemic chiral metabolites for synthesis” Tetrahedron: Asymmetry 2013, 24, 184-190. DOI: 10.1016/j.tetasy.2013.01.002.
6. Trant, J.F.; Hudlicky, T.* “Ring-opening of hindered cyclic epoxides with potassium carboxylates in the presence of conjugate acids” Canadian Journal of Chemistry. 2013, 91, 1179-1185. DOI: 10.1139/cjc-2013-0386.
5. Trant, J.F.; Capiciotti, C.; Biggs, R. A.; Ben, R.N.* “Development of highly active small molecule inhibitors of ice recrystallization” RSC Advances 2013, 3, 26005-26009. DOI: 10.1039/C3RA43835J.
4. Balcerzak, A.K.; Ferreira, S.S.; Trant, J.F.; Ben, R.N.* “Structurally diverse disaccharide analogs of antifreeze glycoproteins and their ability to inhibit ice recrystallization.” Bioorganic & Medicinal Chemistry Letters 2012 22, (4) 1719-1721. DOI: 10.1016/j.bmcl.2011.12.097.
3. Trant, J.F.; Belding, L.; Dudding, T.; Hudlicky, T.* “Application of D-Chiro-inositol as a chiral template for the Diels-Alder reaction” Helvetica Chimica Acta, 2012, 95, 2026-2035. (Invited contribution) DOI: 10.1002/hlca.201200432.
2. Capiciotti, C.J.; Trant, J.F.; Leclère, M.; Ben, R.N.* “Synthesis of C-linked triazole-containing AFGP analogues and their ability to inhibit ice recrystallization.” Bioconjugate Chemistry. 2011, 22, (4), 605-616. DOI: 10.1021/bc100394k.
1. Lemay, M.; Trant, J.; Ogilvie, W.W.* (2007) “Hydrazide Catalysed 1,3-dipolar nitrone cycloadditions.” Tetrahedron. 2007, 63 (47) 11644-11655. DOI: 10.1016/j.tet.2007.08.110.
